This study tests if polyclonal SARS-CoV-2 antibodies enhance disease in ferrets, finding no significant differences in symptoms or viral shedding between antibody-treated and control groups.

bioRxiv · Aug 19, 2023 · PreprintMicrobiology

Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus.

H. Ma, J. Albe, T. Gilliland, C. McMillen, C. Gardner, D. Boyles, E. Cottle, M. Dunn, J. Lundy, N. Salama, K. O'Malley, I. Pandrea, T. Teichert, S. Barrick, W. Klimstra, , D. S. Reed

This study shows that VEEV persists in the CNS of macaques long after acute infection, with ongoing inflammation and immune cell infiltration.

bioRxiv · Sep 9, 2021Immunology

Protection of human ACE2 transgenic Syrian hamsters from SARS CoV-2 variants by human polyclonal IgG from hyper-immunized transchromosomic bovines

T. Gilliland, Y. Liu, R. Li, M. Dunn, E. Cottle, Y. Terada, Z. Ryckman, M. Alcorn, S. Vasilatos, J. D. Lundy, D. Larson, H. Wu, T. Luke, C. Bausch, K. Egland, , W. Klimstra

This study evaluates the neutralizing capacity and protective efficacy of human polyclonal IgG against SARS-CoV-2 variants in vitro and in a transgenic hamster model.

bioRxiv · Jul 26, 2021 · PreprintMicrobiology

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

W. B. Klimstra, N. L. Tilston-Lunel, S. Nambulli, J. Boslett, C. M. McMillen, T. Gilliland, M. D. Dunn, C. Sun, S. E. Wheeler, A. Wells, A. L. Hartman, A. K. McElroy, D. S. Reed, L. J. Rennick, W. P. Duprex

The paper investigates SARS-CoV-2 growth, furin-cleavage-site adaptation, and neutralization using serum from hospitalized COVID-19 patients, finding neutralizing antibody titers are comparable regardless of furin cleavage signal integrity.

bioRxiv · Jun 19, 2020Microbiology