W. B. Klimstra

Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus

This study identifies multiple VLDLR binding sites used by EEEV and develops a decoy receptor to neutralize infection.

Phagocyte-expressed glycosaminoglycans promote capture of alphaviruses from the blood circulation in a host species-specific manner.

This study shows that phagocyte-expressed glycosaminoglycans mediate species-specific vascular clearance of alphaviruses, with some viruses being cleared faster than others.

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants.

This paper describes a fully human immunoglobulin from transchromosomic bovines that neutralizes SARS-CoV-2 variants, including those with mutations like E484K and N501Y.

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

The paper investigates SARS-CoV-2 growth, furin-cleavage-site adaptation, and neutralization using serum from hospitalized COVID-19 patients, finding neutralizing antibody titers are comparable regardless of furin cleavage signal integrity.

Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis.

This paper develops a telemetry method to monitor EEG and ICP in macaques with alphavirus encephalitis, showing changes in brain activity and pressure associated with infection.

Encephalitic alphaviruses exploit caveolae-mediated transcytosis at the blood-brain barrier for CNS entry

This study shows alphaviruses use caveolae-mediated transcytosis across the blood-brain barrier to enter the CNS, and IFN restricts this process.

A vibrating mesh nebulizer as an alternative to the Collison 3-jet nebulizer for infectious disease aerobiology.

The paper compares a vibrating mesh nebulizer (Aeroneb) to the Collison 3-jet nebulizer for generating infectious bioaerosols, finding it suitable for viral pathogens but not for bacteria.