This study tests if polyclonal SARS-CoV-2 antibodies enhance disease in ferrets, finding no significant differences in symptoms or viral shedding between antibody-treated and control groups.

bioRxiv · Aug 19, 2023 · PreprintMicrobiology

Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virus.

H. Ma, J. Albe, T. Gilliland, C. McMillen, C. Gardner, D. Boyles, E. Cottle, M. Dunn, J. Lundy, N. Salama, K. O'Malley, I. Pandrea, T. Teichert, S. Barrick, W. Klimstra, , D. S. Reed

This study shows that VEEV persists in the CNS of macaques long after acute infection, with ongoing inflammation and immune cell infiltration.

bioRxiv · Sep 9, 2021Immunology

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

S. Nambulli, Y. Xiang, N. L. Tilston-Lunel, L. J. Rennick, Z. Sang, W. B. Klimstra, D. S. Reed, N. A. Crossland, Y. Shi, P. W. Duprex

bioRxiv · Feb 23, 2021Microbiology

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and prolonged shedding of infectious virus from both respiratory and gastrointestinal tracts

A. L. Hartman, S. Nambulli, C. M. McMillen, A. G. White, N. Tilston-Lunel, J. R. Albe, E. L. Cottle, M. D. Dunn, L. J. Frye, T. H. Gilliland, E. L. Olsen, K. J. O'Malley, M. M. Schwarz, J. A. Tomko, R. C. Walker, , W. P. Duprex

bioRxiv · Jun 20, 2020Microbiology

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

W. B. Klimstra, N. L. Tilston-Lunel, S. Nambulli, J. Boslett, C. M. McMillen, T. Gilliland, M. D. Dunn, C. Sun, S. E. Wheeler, A. Wells, A. L. Hartman, A. K. McElroy, D. S. Reed, L. J. Rennick, W. P. Duprex

The paper investigates SARS-CoV-2 growth, furin-cleavage-site adaptation, and neutralization using serum from hospitalized COVID-19 patients, finding neutralizing antibody titers are comparable regardless of furin cleavage signal integrity.

bioRxiv · Jun 19, 2020Microbiology

Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis.

H. Ma, J. D. Lundy, E. L. Cottle, K. J. O'Malley, A. M. Trichel, W. B. Klimstra, A. L. Hartman, D. S. Reed, T. Teichert

This paper develops a telemetry method to monitor EEG and ICP in macaques with alphavirus encephalitis, showing changes in brain activity and pressure associated with infection.

bioRxiv · Apr 15, 2020Immunology

A vibrating mesh nebulizer as an alternative to the Collison 3-jet nebulizer for infectious disease aerobiology.

J. D. Bowling, K. J. O'Malley, W. B. Klimstra, A. L. Hartman, D. S. Reed

The paper compares a vibrating mesh nebulizer (Aeroneb) to the Collison 3-jet nebulizer for generating infectious bioaerosols, finding it suitable for viral pathogens but not for bacteria.

bioRxiv · Mar 31, 2019Microbiology

Development, characterization and standardization of a nose-only inhalation exposure system for exposure of rabbits to small particle aerosols containing Francisella tularensis.

K. J. O'Malley, J. D. Bowling, E. M. Barry, K. R. O. Hazlett, D. S. Reed

This paper develops and optimizes a nose-only inhalation system for exposing rabbits to Francisella tularensis aerosols, improving dose accuracy and evaluating vaccine efficacy.

bioRxiv · Mar 9, 2019Microbiology