Author

N. Sluis-Cremer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Gerberick· 1 shared A. V. Rivera· 1 shared B. Vargas· 1 shared C. Aiken· 1 shared C. R. Rinaldo· 1 shared D. C. DeLucia· 1 shared D. T. Nguyen· 1 shared G. Calero· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. Gerberick

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structures of kinetic intermediate states of HIV-1 reverse transcriptase DNA synthesis

S. Vergara, X. Zhou, U. Santiago, J. F. Conway, N. Sluis-Cremer, G. Calero

This study captures 11 structures of HIV-1 reverse transcriptase during DNA synthesis, revealing intermediate states and mechanisms of dATP incorporation and drug resistance.

bioRxiv · Dec 18, 2023 · PreprintBiophysics

The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

C. Aiken, J. Jennings, H. Bracey, D. T. Nguyen, R. Dasgupta, A. V. Rivera, N. Sluis-Cremer, J. Shi

This study shows that HIV-1 capsid acts as a nanoscale container for reverse transcription, with NERT activity dependent on gp41 and not requiring IP6 or a mature capsid.

bioRxiv · Nov 8, 2023Microbiology

Mechanism by which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency

N. Sluis-Cremer, B. Vargas, N. A. Yates, J. Boslett

This study identifies PF-3758309 as a PAK inhibitor that blocks HIV-1 latency reversal by downregulating NF-κB signaling, with PAK1 and PAK2 playing key roles in latency maintenance.

bioRxiv · Aug 2, 2022Microbiology

B LYMPHOCYTES, BUT NOT DENDRITIC CELLS, EFFICIENTLY HIV-1 TRANS-INFECT NAÏVE CD4+ T CELLS: IMPLICATIONS FOR THE VIRAL RESERVOIR

A. Gerberick, D. C. DeLucia, P. A. Piazza, M. Alaoui-El-Azher, C. R. Rinaldo, N. Sluis-Cremer, G. Rappocciolo

bioRxiv · Oct 22, 2020Microbiology