J. Bravo

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases

This study investigates the catalytic mechanisms and substrate specificity of the lactonase GcL, revealing its promiscuity in reaction mechanisms and broad substrate acceptance.

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune Diseases

This paper introduces Ingenui-T, a method for rapid CAR T-cell manufacturing from whole blood, showing comparable or better functional activity than conventional methods.

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

Molecular and evolutionary mechanisms of yeast thermotolerance

The paper investigates the molecular and evolutionary mechanisms underlying thermotolerance in yeast, identifying positive selection at the ESP1 gene and its functional impact on growth at high temperatures.