Author

J. Villanueva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Physiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:benchmark study· 1

Frequent Co-Authors

G. M. Alicea· 2 shared Q. Liu· 2 shared V. W. Rebecca· 2 shared A. B. Warner· 1 shared A. Benito-Martin· 1 shared A. García de Herreros· 1 shared A. Kossenkov· 1 shared A. Millanes-Romero· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

G. M. Alicea

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

V. W. Rebecca, M. Xiao, A. Kossenkov, T. Godok, G. S. Brown, D. Fingerman, G. M. Alicea, M. Wei, H. Ji, J. Bravo, Y. Chen, M. E. Fane, J. Villanueva, K. L. Nathanson, Q. Liu, , M. Herlyn

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

bioRxiv · Jan 20, 2023 · PreprintCancer Biology

Diversity, Equity, and Inclusion in the Melanoma Research Community

M. E. Portuallo, D. Y. Lu, G. M. Alicea, J. Bolling, R. Lee, J. McQuade, A. B. Warner, M. Davies, A. Weeraratna, J. Villanueva, V. W. Rebecca

The paper assesses diversity, equity, and inclusion in the melanoma research community through an international survey, revealing significant inequities related to gender, ethnicity, and geography.

bioRxiv · Sep 24, 2022Scientific Communication & Education

Mast cells impair melanoma cell homing and metastasis by inhibiting HMGA1 secretion.

A. Benito-Martin, M. Hergueta-Redondo, L. Nogues, E. Castellano-Sanz, E. Garvin, M. Cioffi, P. Sola-Castrillo, W. Buehring, M. P. Ximenez-Embun, J. Munoz, I. Matei, J. Villanueva, H. Peinado

This study shows mast cells inhibit melanoma metastasis by reducing HMGA1 secretion, with HMGA1 expression linked to poorer survival in human melanoma.

bioRxiv · May 31, 2022Cancer Biology

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma

B. Lipchick, A. N. Guterres, H.-Y. Chen, D. M. Zundell, S. Del Aguila, P. I. Reyes-Uribe, S. Basu, X. Yin, A. V. Kossenkov, Y. Lu, G. B. Mills, Q. Liu, A. R. Goldman, M. E. Murphy, D. W. Speicher, J. Villanueva

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

bioRxiv · Apr 7, 2021 · PreprintCancer Biology

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury

M. Redd, S. Scheuer, N. Saez, H. Chiu, L. Gao, M. Hicks, J. Villanueva, G. Cuellar-Partida, J. Peart, L. See Hoe, X. Chen, Y. Sun, J. Suen, R. Hatch, B. Rollo, , N. Palpant

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

bioRxiv · Nov 17, 2020Physiology

Maintaining oxidized H3 in heterochromatin is required for the oncogenic capacity of triple-negative breast cancer cells

G. Serra-Bardenys, T. V. Tian, E. Blanco, J. Querol, L. Pascual-Reguant, B. Morancho, M. Escorihuela, S. Segura-Bayona, G. Verde, R. Aiese Cigliano, A. Millanes-Romero, C. Jerónimo, P. Nuciforo, S. Simonetti, C. Viaplana, , S. Peiró

This study identifies the role of H3K4ox in maintaining heterochromatin structure in TNBC cells and shows its necessity for oncogenic properties.

bioRxiv · Jan 30, 2020 · PreprintCancer Biology