Parsing the role of NSP1 in SARS-CoV-2 infection
T. Fisher, A. Gluck, K. Narayanan, M. Kuroda, A. Nachshon, J. C Hsu, P. J Halfmann, Y. Yahalom-Ronen, Y. Finkel, M. Schwartz, S. Weiss, C.-T. K Tseng, T. Israely, N. Paran, Y. Kawaoka, , N. Stern-Ginossar
This study investigates the role of SARS-CoV-2 nsp1 in host shutoff and immune evasion, finding it inhibits translation and induces mRNA degradation, and is critical for counteracting the IFN response.
bioRxiv · Mar 14, 2022Microbiology