N. Stern-Ginossar

A virally encoded high resolution screen of cytomegalovirus host dependencies

This study develops VECOS, a viral-encoded CRISPR screen to analyze host dependencies during cytomegalovirus infection, identifying novel factors and revealing the importance of virion assembly.

The molecular principles governing HCMV infection outcome

This study identifies molecular factors determining HCMV infection outcomes in macrophages and monocytes using single-cell transcriptomics, revealing that viral gene expression and intrinsic ISG levels dictate productive vs. non-productive infection.

Parsing the role of NSP1 in SARS-CoV-2 infection

This study investigates the role of SARS-CoV-2 nsp1 in host shutoff and immune evasion, finding it inhibits translation and induces mRNA degradation, and is critical for counteracting the IFN response.

Temporal Dynamics of HCMV Gene Expression in Lytic and Latent Infections

This study examines HCMV gene expression dynamics during productive and latent infections, revealing that viral gene regulation is not a simple sequential cascade and that IE genes are uniquely repressed in latency.

CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2.

This study uses CRISPR screens to identify host factors critical for SARS-CoV-2 infection, finding GATA6 as a key modulator of ACE2 expression and viral entry.

SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis

This study identifies how SARS-CoV-2 suppresses host protein synthesis through global translation reduction, mRNA degradation, and impaired translation of immune-related transcripts.

The coding capacity of SARS-CoV-2

This study maps the full coding capacity of SARS-CoV-2 using ribosome profiling, identifying 23 novel translated ORFs and revealing viral translation dominance over host translation.

Comprehensive Annotations of Human Herpesvirus 6A and 6B Genomes Reveal Novel and Conserved Genomic Features

This study identifies hundreds of new ORFs and lncRNAs in HHV-6A and B genomes, revealing conserved features across betaherpesviruses.

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

This study uses single-cell RNA sequencing to analyze HCMV latency and finds no evidence of a restricted latency-associated gene expression program, instead showing gene expression patterns similar to late lytic stages at lower levels.