Author

Y. Finkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:genetic perturbation / CRISPR· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Nachshon· 6 shared N. Stern-Ginossar· 6 shared M. Schwartz· 5 shared N. Paran· 4 shared A. Gluck· 3 shared T. Israely· 3 shared Y. Yahalom-Ronen· 3 shared A. Beth-Din· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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6 shared papersMicrobiology

A. Nachshon

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A virally encoded high resolution screen of cytomegalovirus host dependencies

Y. Finkel, A. Nachshon, E. Aharon, T. Arazi, E. Simonovsky, M. Dobesova, A. Gluck, T. Fisher, R. J. Stanton, M. Schwartz, N. Stern-Ginossar

This study develops VECOS, a viral-encoded CRISPR screen to analyze host dependencies during cytomegalovirus infection, identifying novel factors and revealing the importance of virion assembly.

bioRxiv · Oct 30, 2023 · PreprintMicrobiology

Parsing the role of NSP1 in SARS-CoV-2 infection

T. Fisher, A. Gluck, K. Narayanan, M. Kuroda, A. Nachshon, J. C Hsu, P. J Halfmann, Y. Yahalom-Ronen, Y. Finkel, M. Schwartz, S. Weiss, C.-T. K Tseng, T. Israely, N. Paran, Y. Kawaoka, , N. Stern-Ginossar

This study investigates the role of SARS-CoV-2 nsp1 in host shutoff and immune evasion, finding it inhibits translation and induces mRNA degradation, and is critical for counteracting the IFN response.

bioRxiv · Mar 14, 2022Microbiology

CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2.

M. Israeli, Y. Finkel, Y. Yahalom-Rone, N. Paran, T. Chitlaru, O. Israeli, I. Cohen-Gihon, M. Aftalion, R. Falach, U. Elia, I. Nemet, L. Kliker, M. Mandelboim, A. Beth-Din, T. Israely, , A. Bercovich-Kinori

This study uses CRISPR screens to identify host factors critical for SARS-CoV-2 infection, finding GATA6 as a key modulator of ACE2 expression and viral entry.

bioRxiv · Jul 19, 2021 · PreprintMicrobiology

SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis

Y. Finkel, A. Gluck, R. Winkler, A. Nachshon, O. Mizrahi, Y. Lubelsky, B. Zuckerman, B. Slobodin, Y. Yahalom-Ronen, H. Tamir, I. Ulitsky, T. Israely, N. Paran, M. Schwartz, N. Stern-Ginossar

This study identifies how SARS-CoV-2 suppresses host protein synthesis through global translation reduction, mRNA degradation, and impaired translation of immune-related transcripts.

bioRxiv · Nov 25, 2020Microbiology

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

S. Weingarten-Gabbay, S. Klaeger, S. Sarkizova, L. R. Pearlman, D.-Y. Chen, M. R. Bauer, H. B. Taylor, H. L. Conway, C. H. Tomkins-Tinch, Y. Finkel, A. Nachshon, M. Gentili, K. D. Rivera, D. B. Keskin, C. M. Rice, , P. C. Sabeti

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

bioRxiv · Oct 2, 2020 · PreprintImmunology

The coding capacity of SARS-CoV-2

Y. Finkel, O. Mizrahi, A. Nachshon, S. Weingarten-Gabbay, D. Morgenstern, Y. Yahalom-Ronen, H. Tamir, H. Achdout, D. Stein, O. Israeli, A. Beth-Din, S. Melamed, S. Weiss, T. Isrealy, N. Paran, , N. Stern-Ginossar

This study maps the full coding capacity of SARS-CoV-2 using ribosome profiling, identifying 23 novel translated ORFs and revealing viral translation dominance over host translation.

Nature · Sep 9, 2020Peer-reviewedMicrobiology

Comprehensive Annotations of Human Herpesvirus 6A and 6B Genomes Reveal Novel and Conserved Genomic Features

Y. Finkel, D. Schmiedel, J. Tai-Schmiedel, A. Nachshon, M. Schwartz, O. Mandelboim, N. Stern-Ginossar

This study identifies hundreds of new ORFs and lncRNAs in HHV-6A and B genomes, revealing conserved features across betaherpesviruses.

bioRxiv · Aug 8, 2019Microbiology