Cardiac Troponin I Directly Binds and Inhibits Mitochondrial ATP Synthase: a Noncanonical Role in the Post-Ischemic Heart
A. Elezaby, A. J. Lin, V. Vijayan, S. Pokhrel, L. R. Bechara, N. P. Ostberg, B. B. Queliconi, J. C. Campos, J. C. Ferreira, B. Haileselassie, D. Mochly-Rosen
This study identifies a noncanonical role of cardiac troponin I in inhibiting mitochondrial ATP synthase, showing that blocking this interaction reduces cardiac injury during ischemia.
bioRxiv · Feb 3, 2023Cell Biology