A Standalone PD-1 Chimeric Switch Receptor T-Cell Platform Expands the Therapeutic Window of PD-L1 Targeting in Solid Tumors
Y. Luo, S. Guo, Y. Qie, B. Zhao, M. J. Ulloa-Navas, M. Brooks, V. Jones, T. Hundal, J. C. Chavez, Y. Lou, L. P. Deleyrolle, V. Velcheti, J. W. Jakub, R. Dronca, M. A. Kharfan-Dabaja, , Hong Qin
This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.
bioRxiv · Nov 9, 2026 · PreprintMolecular Biology