Y. Qie

A Standalone PD-1 Chimeric Switch Receptor T-Cell Platform Expands the Therapeutic Window of PD-L1 Targeting in Solid Tumors

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment

This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.

CAR T-cell therapy- Paving the way for sensitized kidney transplant patients.

This paper explores using CAR T-cells targeting BAFF-R to treat sensitized kidney transplant patients, showing cytotoxicity against autologous B cells and paving the way for clinical trials.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.