Author

J. C. Rayner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:plant (other)· 4 Organism:human· 3 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Marin-Menendez· 2 shared K. Mwikali· 2 shared M. Carrasquilla· 2 shared T. Sanderson· 2 shared V. Introini· 2 shared A. Knudson Ospina· 1 shared A. L. Smith· 1 shared A. M. Early· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. Marin-Menendez

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The structure of a Plasmodium vivax Tryptophan Rich Antigen suggests a lipid binding function for a pan-Plasmodium multi-gene family

P. Kundu, D. Naskar, S. McKie, S. Dass, U. Kanjee, V. Introini, M. U. Ferreira, M. Duraisingh, J. E. Deane, J. C. Rayner

The paper determines the structure of a Plasmodium vivax TRAg and shows it binds lipids, suggesting a role in membrane remodeling during red blood cell invasion.

bioRxiv · Sep 30, 2022Microbiology

Barcoding genetically distinct Plasmodium falciparum strains for comparative assessment of fitness and antimalarial drug resistance

M. Carrasquilla, N. F. Drammeh, M. Rawat, T. Sanderson, Z. Zenonos, J. C. Rayner, M. Lee

This paper introduces a method to assess fitness and drug resistance in Plasmodium falciparum strains using CRISPR/Cas9 and barcode sequencing, demonstrating its ability to detect artemisinin resistance in mixed parasite populations.

bioRxiv · Apr 5, 2022Microbiology

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

M. Carrasquilla, A. M. Early, A. R. Taylor, A. Knudson Ospina, D. F. Echeverry, T. J. Anderson, E. Mancilla, S. Aponte, P. Cárdenas, C. O. Buckee, J. C. Rayner, F. E. Sáenz, D. E. Neafsey, V. Corredor

This study uses identity-by-descent analysis on whole-genome sequences from Plasmodium falciparum to examine drug resistance and population structure in a low-transmission, inbred population.

bioRxiv · Feb 18, 2022Evolutionary Biology

The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion

V. Introini, A. Marin-Menendez, G. Nettesheim, Y.-C. Lin, S. N. Kariuki, A. L. Smith, L. Jean, J. N. Brewin, D. C. Rees, P. Cicuta, J. C. Rayner, B. S. Penman

This study examines beta thalassaemia heterozygous erythrocytes' properties and their effect on Plasmodium falciparum invasion, finding no overall reduction in invasion efficiency.

bioRxiv · Jan 13, 2022Microbiology

STEM CELL TECHNOLOGY PROVIDES NOVEL TOOLS TO UNDERSTAND HUMAN VARIATION IN Plasmodium falciparum MALARIA

A. Pance, B. Ling, K. Mwikali, M. Koutsourakis, C. Agu, F. Rouhani, H. Ponstingl, R. Montandon, F. Law, J. C. Rayner

The paper uses stem cell technology to study human genetic variation's impact on Plasmodium falciparum malaria by generating erythrocytes from diverse stem cell lines and analyzing parasite invasion.

bioRxiv · Jun 30, 2021 · PreprintCell Biology

Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

D. N. Ndegwa, J. B. Hostetler, A. Marin-Menendez, T. Sanderson, K. Mwikali, L. H. Verzier, R. Coyle, S. Adjalley, J. C. Rayner

This paper uses Plasmodium knowlesi as a model to screen Plasmodium vivax blood-stage vaccine targets, identifying new candidates by testing antibody inhibition of parasite invasion.

bioRxiv · Aug 7, 2020Microbiology

Plasmodium falciparum schizont stage transcriptome variation among clinical isolates and laboratory-adapted clones

S. J. Tarr, O. Diaz-Ingelmo, L. B. Stewart, S. E. Hocking, L. Murray, C. W. Duffy, T. D. Otto, L. Chappell, J. C. Rayner, G. A. Awandare, D. J. Conway

The paper analyzes transcriptome variation in Plasmodium falciparum schizonts across clinical isolates and lab-adapted clones using RNA-seq, identifying genes with differential expression and validating findings with RT-qPCR.

bioRxiv · Jun 22, 2018Cell Biology