T. J. Anderson

Contribution of parasite and host genotype to immunopathology of schistosome infections

This study investigates how parasite and host genetics influence immunopathology and infection outcomes in Schistosoma mansoni infections in mice.

No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host

This study investigates whether schistosome parasites with high cercariae shedding in snails have lower fitness in rodent hosts, but finds positive pleiotropy between hosts.

Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis

This study uses identity-by-descent analysis on whole-genome sequences from Plasmodium falciparum to examine drug resistance and population structure in a low-transmission, inbred population.

Fitness costs of pfhrp2 and pfhrp3 deletions underlying diagnostic evasion in malaria parasites

The paper measures fitness costs of pfhrp2 and pfhrp3 deletions in malaria parasites using CRISPR/Cas9 and competition experiments, finding costs consistent with diagnostic selection driving their spread in some regions.

Genomic analysis of a parasite invasion: colonization of the Americas by the blood fluke, Schistosoma mansoni

This study analyzes genomic data from Schistosoma mansoni to determine if there was a population bottleneck during its colonization of the Americas and identifies regions under selection.

Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations

This study shows that fitness costs of antimalarial drug resistance mutations are significantly higher in nutrient-limited media compared to standard RPMI, suggesting underestimation in typical lab conditions.

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

The paper identifies widespread oxamniquine resistance alleles in Old World Schistosoma mansoni populations, showing they predate drug use and exist as standing genetic variation.