Author

J. C. Schwartz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. A. Lay· 3 shared V. F. Thompson· 3 shared D. R. Wieland· 2 shared L. M. Harrell· 2 shared A. D. Adelakun· 1 shared A. McNee· 1 shared A. R. Townsend· 1 shared B. Clark· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

M. A. Lay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks

M. A. Lay, V. F. Thompson, A. D. Adelakun, J. C. Schwartz

This study identifies how EWSR1 recognizes R-loops by binding DNA forks, revealing the role of its ZnF and RRM domains in specificity.

bioRxiv · Jan 20, 2024Biochemistry

FUS binding to RNA prevents R-loops

V. F. Thompson, D. R. Wieland, V. Mendoza-Leon, H. I. Janis, M. A. Lay, L. M. Harrell, J. C. Schwartz

This study shows FUS binds nascent transcripts to prevent R-loop formation, reducing their impact on transcription and RNA metabolism.

bioRxiv · Aug 11, 2022 · PreprintBiochemistry

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

B. Holzer, P. Rijal, A. McNee, B. Paudyal, B. Clark, T. Manjegowda, F. J. Salguero, E. Bessell, J. C. Schwartz, K. Moffat, M. Pedrera, S. P. Graham, M. B.-D. Placido, R. M. La Ragione, W. Mwangi, , E. Tchilian

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.

bioRxiv · Jul 21, 2020Immunology

Fusion protein EWS-FLI1 is incorporated into a protein granule in cells

N. S. Ahmed, L. M. Harrell, D. R. Wieland, M. A. Lay, V. F. Thompson, J. C. Schwartz

The paper investigates how EWS-FLI1 forms protein assemblies and its role in gene regulation in Ewing sarcoma cells.

bioRxiv · May 31, 2020 · PreprintBiochemistry

Discriminating changes in protein structure using PTAD conjugation to tyrosine

M. Moinpour, N. K. Barker, L. E. Guzman, J. C. Jewett, P. R. Langlais, J. C. Schwartz

This study uses PTAD conjugation to tyrosine to distinguish conformational states of proteins by measuring PTAD labeling depth relative to the protein surface.

bioRxiv · Feb 4, 2020Biochemistry