B. Paudyal

Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung

This study uses single-cell RNA sequencing and flow cytometry to analyze immunological changes in pig lungs after influenza infection or vaccination, revealing lasting effects on immune cell populations and function.

Low dose pig anti-influenza virus monoclonal antibodies reduce lung pathology but do not prevent virus shedding

This study shows that high-dose pig monoclonal antibodies reduce lung pathology and virus load but not nasal shedding, suggesting lower doses may suffice for disease severity reduction.

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.

The paper identifies and characterizes influenza NP-specific CD8 T cells in porcine tissues, showing their persistence and gene expression changes in the lung.

Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination

This study shows that co-infection with PRRSV-2 and H3N2 virus reduces the protective effect of PRRS MLV vaccination against clinical disease.

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

This study compares T cell and antibody responses to H1N1pdm09 infection in inbred and outbred pigs, showing similar immune responses despite differences in genetic background.

Simultaneous aerosol and intra-muscular immunization with influenza vaccine induces powerful protective local T cell and systemic Ab immune responses in pigs

This study evaluates simultaneous aerosol and intramuscular influenza vaccination in pigs, finding that combined immunization induces both strong antibody and local T cell responses, leading to better virus control.

Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

This study generates pig-specific monoclonal antibodies against H1N1pdm09 influenza virus that target human-like HA epitopes and reduce disease severity in pigs.