Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors
J. S. Smith, T. F. Pack, A. Inoue, C. Lee, X. Xiong, K. Zheng, A. W. Kahsai, I. Choi, Z. Ma, I. M. Levitan, L. K. Rochelle, D. P. Staus, J. C. Snyder, M. G. Caron, S. Rajagopal
The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.
bioRxiv · May 7, 2019Cell Biology