Author

M. G. Caron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. B. Pinkerton· 1 shared A. Inoue· 1 shared A. W. Kahsai· 1 shared B. E. Krumm· 1 shared B. L. Roth· 1 shared C. Lee· 1 shared D. P. Staus· 1 shared H. J. Kang· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. B. Pinkerton

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Author profile →

2 papers

Recent·Most cited

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

B. E. Krumm, J. F. DiBerto, R. H. J. Olsen, H. J. Kang, S. T. Slocum, S. Zhang, R. T. Strachan, L. M. Slosky, A. B. Pinkerton, L. S. Barak, M. G. Caron, T. Kenakin, B. L. Roth

This study reveals the cryoEM structures of NTSR1 with and without SBI-553, showing its biased allosteric modulation of G protein and β-Arrestin signaling.

bioRxiv · Dec 26, 2022 · PreprintBiophysics

Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

J. S. Smith, T. F. Pack, A. Inoue, C. Lee, X. Xiong, K. Zheng, A. W. Kahsai, I. Choi, Z. Ma, I. M. Levitan, L. K. Rochelle, D. P. Staus, J. C. Snyder, M. G. Caron, S. Rajagopal

The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.

bioRxiv · May 7, 2019Cell Biology