K. Zheng

A Comprehensive Model to Differentiate Spontaneous, Drug-induced, and CSCs-related Drug Resistance

This study develops a mathematical model to differentiate types of drug resistance and evaluates treatment strategies, finding that bolus injection can extend survival at equivalent cumulative dosages.

Mitochondrial respiration is essential for photosynthesis-dependent ATP supply of the plant cytosol

This study shows mitochondrial respiration is essential for ATP supply to the cytosol in photosynthesizing plant cells, using moss as a model.

Modeling Sex Differences in the Effects of Diuretics in Renal Epithelial Transport during Angiotensin II-induced Hypertension

This study develops sex-specific computational models to analyze how diuretics affect renal electrolyte transport differently in male and female rats under hypertension.

The proteome of agroinfiltrated Nicotiana benthamiana is shaped by extensive protein processing

The paper identifies extensive proteolytic processing of plant proteins in agroinfiltrated N. benthamiana using peptographs and mass spectrometry, revealing widespread proteoform modifications.

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

The paper identifies increased mTORC1 activity in CRSwNP epithelial cells and links it to cytokine production and inflammation in both CRSwNP and asthma.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

E6AP is important for HPV E6 role in regulating epithelial homeostasis and its loss impairs keratinocyte commitment to differentiation

The paper shows E6AP is critical for HPV E6 regulation of epithelial homeostasis, with its loss impairing keratinocyte differentiation and YAP activation.

Location bias contributes to functionally selective responses of biased CXCR3 agonists

The paper shows that biased CXCR3 agonists produce different signaling outcomes based on subcellular location, with endosomal signaling playing a key role in biased activation.

Alisertib exerts KRAS allele specific anticancer effects in colorectal cancer

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

In vivo validation of spray-dried mesoporous bioactive glass microspheres acting as prolonged local release systems for BMP-2 to induce bone regeneration

This study validates spray-dried mesoporous bioactive glass microspheres as a prolonged BMP-2 release system to enhance bone regeneration with reduced side effects.

Global reinforcement of DNA methylation through enhancement of RNA-directed DNA methylation ensures sexual reproduction in rice

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiate the DNA damage response and repair

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors

The paper demonstrates that Gαi proteins can form complexes with β-arrestin, independent of their canonical G protein coupling, and these complexes can bind GPCRs and ERK.

Long noncoding RNAs sustain high expression of exogenous Oct4 by sponging miRNA during reprogramming

The paper shows lncRNAs and circRNAs sponge miRNAs to maintain Oct4 expression during reprogramming, enhancing reprogramming efficiency.

The gut microbiota regulates mouse biliary regenerative responses

This study shows that gut microbiota influences biliary regenerative responses in mice, with butyrate playing a role in inhibiting fibrosis.

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

This study shows that PLEKHO1 in osteoblasts worsens joint inflammation in RA and promotes bone formation, suggesting it as a therapeutic target.

Rice TSV3 Encoding Obg-like GTPase Protein is Essential for Chloroplast Development during the Early Leaf Stage under Cold Stress

Cas13b is a Type VI-B CRISPR-associated RNA-Guided RNase differentially regulated by accessory proteins Csx27 and Csx28

The paper identifies two CRISPR-Cas VI-B systems with Cas13b and characterizes their RNA interference activity and regulation by Csx27 and Csx28.