Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
K. M. R. Faysal, J. C. Walsh, N. Renner, C. L. Marquez, V. Shah, A. J. Tuckwell, M. P. Christie, M. W. Parker, S. G. Turville, L. James, G. J. Towers, D. A. Jacques, T. Boecking
This study shows Lenacapavir's antiviral effect comes from hyperstabilizing the HIV-1 capsid lattice, leading to loss of compartmentalization and capsid failure.
bioRxiv · Sep 21, 2022Biophysics