Author

J. C. Widen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Bogyo· 2 shared A. antaris· 1 shared A. Klaassen· 1 shared B. Cerikan· 1 shared B. M. Babin· 1 shared C. Peters· 1 shared H. Kim· 1 shared J. J. Yim· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

M. Bogyo

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2 papers

Recent·Most cited

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

K. Steuten, H. Kim, J. C. Widen, B. M. Babin, O. Onguka, S. Lovell, O. Bolgi, B. Cerikan, M. Cortese, R. K. Muir, J. M. Bennett, R. Geiss-Friedlander, C. Peters, R. Bartenschlager, M. Bogyo

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

bioRxiv · Nov 21, 2020Microbiology

Multivariate 'AND-gate' substrate probes as enhanced contrast agents for fluorescence-guided surgery

J. C. Widen, M. Tholen, J. J. Yim, A. antaris, K. M. Casey, S. Rogalla, A. Klaassen, J. Sorger, M. Bogyo

This paper introduces multivariate AND-gate optical imaging probes that improve specificity and sensitivity for cancer margin detection during surgery by requiring sequential processing by multiple tumor-specific enzymes.

bioRxiv · Jun 8, 2020 · PreprintBioengineering