B. M. Babin

A screen of covalent inhibitors in Mycobacterium tuberculosis identifies serine hydrolases involved in lipid metabolism as potential therapeutic targets

Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host

This study identifies serine hydrolases in Toxoplasma gondii that hydrolyze lipid esters, showing their role in lipid metabolism and potential as therapeutic targets.

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

A chemiluminescent protease probe for rapid, sensitive, and inexpensive detection of live Mycobacterium tuberculosis

A chemiluminescent probe detects live Mycobacterium tuberculosis with high sensitivity and speed, enabling improved TB diagnostics and drug resistance monitoring.

Leveraging peptide substrate libraries to design inhibitors of bacterial Lon protease

The paper uses peptide substrate libraries to determine the specificity of bacterial Lon protease and develops a potent inhibitor that affects Lon function in E. coli without toxicity to mammalian cells.