Author

M. Tholen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:ecology & biodiversity· 1 Assay:imaging· 1

Frequent Co-Authors

M. Bogyo· 3 shared J. J. Yim· 2 shared A. antaris· 1 shared A. Boettcher· 1 shared A. J. Hryckowian· 1 shared A. Klaassen· 1 shared A. Kostina· 1 shared B. A. Martin· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBioengineering

M. Bogyo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology

Design of optical imaging probes by screening of diverse substrate libraries directly in disease tissue extracts

M. Tholen, J. J. Yim, K. Groborz, E. Yoo, B. A. Martin, N. S. van den Berg, M. Drag, M. Bogyo

The paper develops fluorescent probes for cancer detection by screening peptide libraries in tissue extracts, identifying highly effective tumor-specific probes that outperform previous designs.

bioRxiv · Jun 8, 2020Bioengineering

Multivariate 'AND-gate' substrate probes as enhanced contrast agents for fluorescence-guided surgery

J. C. Widen, M. Tholen, J. J. Yim, A. antaris, K. M. Casey, S. Rogalla, A. Klaassen, J. Sorger, M. Bogyo

This paper introduces multivariate AND-gate optical imaging probes that improve specificity and sensitivity for cancer margin detection during surgery by requiring sequential processing by multiple tumor-specific enzymes.

bioRxiv · Jun 8, 2020 · PreprintBioengineering

The clinical drug candidate ebselen attenuates inflammation and promotes microbiome recovery after antibiotic treatment for Clostridium difficile infection

M. Garland, A. J. Hryckowian, M. Tholen, S. Loscher, W. W. Van Treuren, K. Oresic Bender, J. L. Sonnenburg, M. Bogyo

This study shows ebselen reduces CDI recurrence and colitis in hamsters and promotes microbiome recovery without altering diversity in mice.

bioRxiv · Nov 1, 2019Microbiology