Author

R. Geiss-Friedlander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

O. Bolgi· 2 shared B. Cerikan· 1 shared B. M. Babin· 1 shared B. Ross· 1 shared C. Lenz· 1 shared C. Peters· 1 shared E. Pilla· 1 shared H. Kim· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

O. Bolgi

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Challenges for targeting SARS-CoV-2 proteases as a therapeutic strategy for COVID-19

K. Steuten, H. Kim, J. C. Widen, B. M. Babin, O. Onguka, S. Lovell, O. Bolgi, B. Cerikan, M. Cortese, R. K. Muir, J. M. Bennett, R. Geiss-Friedlander, C. Peters, R. Bartenschlager, M. Bogyo

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

bioRxiv · Nov 21, 2020Microbiology

Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

M. Silva-Garcia, O. Bolgi, B. Ross, E. Pilla, K. Vijayalakshmi, M. Killisch, N. Stark, C. Lenz, M. Spitzner, M. D. Gorrell, M. Grade, H. Urlaub, M. Dobbelstein, R. Huber, R. Geiss-Friedlander

This study identifies DPP9 as a regulator of BRCA2 stability and DNA-damage repair by promoting its degradation via the N-degron pathway.

bioRxiv · Aug 24, 2020Biochemistry