Author

A. S. Little

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. E. Greenstein· 1 shared A. G. Moraitis· 1 shared A. Livolsi· 1 shared A. M. Eren· 1 shared A. M. Sidebottom· 1 shared A. Sundararajan· 1 shared A. T. Iavarone· 1 shared C. A. Thorne· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

A. E. Greenstein

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

A. S. Little, I. T. Younker, M. S. Schechter, P. Nol Bernardino, R. Meheust, J. Stemczynski, K. Scorza, M. W. Mullowney, D. Sharan, E. Waligurski, R. Smith, R. Ramanswamy, W. Leiter, D. Moran, M. McMillin, , S. H. Light

The paper identifies gut bacteria that use dietary and host-derived metabolites as electron acceptors in anaerobic respiration, revealing new metabolic pathways and reductase evolution.

bioRxiv · Dec 26, 2022Microbiology

Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators

S. Mallick, J. Chakrabarti, J. Eschbacher, A. G. Moraitis, A. E. Greenstein, J. Churko, K. W. Pond, A. Livolsi, C. A. Thorne, A. S. Little, K. C. Yuen, Y. Zavros

This study uses PitNET organoids to show relacorilant reduces tumor growth and induces apoptosis better than mifepristone, and enhances response to somatostatin analogs.

bioRxiv · Sep 7, 2022Physiology