Author

R. Francescone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Cukierman· 5 shared J. Franco-Barraza· 5 shared T. Luong· 4 shared D. B. Vendramini-Costa· 3 shared D. Restifo· 3 shared I. Astsaturov· 3 shared J. C. Gardiner· 3 shared A. Klochkova· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

E. Cukierman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pulsed low-dose-rate radiation (PLDR) reduces the tumor-promoting responses induced by conventional chemoradiation in pancreatic cancer-associated fibroblasts

J. Franco-Barraza, T. Luong, J. K. Wong, K. Raghavan, E. Handroff, D. B. Vendramini-Costa, R. Francescone, J. C. Gardiner, J. E. Meyer, E. Cukierman

This study shows that pulsed low-dose-rate radiation combined with chemotherapy shifts pancreatic cancer-associated fibroblasts from tumor-promoting to tumor-suppressing, reducing desmoplasia and improving neoadjuvant therapy.

bioRxiv · Jan 13, 2024 · PreprintCancer Biology

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

C. Ogier, A. M. Charles Solomon, Z. Lu, L. Recoules, A. Klochkova, L. Gabitova-Cornell, B. Bayarmagnai, D. Restifo, A. Surumbayeva, D. B. Vendramini-Costa, A. Deneka, R. Francescone, A. C. Lilly, A. Sipman, J. C. Gardiner, , I. Astsaturov

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress

K. S. Raghavan, R. Francescone, J. Franco-Barraza, J. C. Gardiner, D. B. Vendramini-Costa, T. Luong, N. Pourmandi, A. Kurimchak, C. Ogier, J. S. Duncan, C. A. Lyssiotis, L. R. Languino, E. Cukierman

This study identifies NetrinG1+ cancer-associated fibroblasts that produce extracellular vesicles supporting pancreatic cancer cell survival under nutrient stress.

bioRxiv · Nov 21, 2021Cancer Biology

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

R. Francescone, D. Barbosa Vendramini-Costa, J. Franco-Barraza, J. Wagner, A. Muir, A. N. Lau, L. Gabitova, T. Pazina, S. Gupta, T. Luong, N. Shah, D. Rollins, R. Malik, R. Thapa, D. Restifo, , E. Cukierman

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

bioRxiv · May 30, 2020Cancer Biology

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

L. G. Cornell, S. Peri, D. Restifo, A. Klochkova, T. R. Hartman, A. M. O'Reilly, R. Francescone, J. Franco-Barraza, N. Shah, E. Nicolas, E. A. Handorf, K. Q. Cai, A. Mazitova, I. Sloma, R. Chiaverelli, , I. Astsaturov

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.

bioRxiv · May 11, 2019 · PreprintCancer Biology