Author

A. Klochkova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. A. Whelan· 3 shared A. D. Fuller· 2 shared A. Klein-Szanto· 2 shared A. L. Karami· 2 shared A. Mu· 2 shared D. Restifo· 2 shared E. A. Golemis· 2 shared E. Cukierman· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

K. A. Whelan

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Author profile →

5 papers

Recent·Most cited

Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential

A. Klochkova, A. L. Karami, A. D. Fuller, L. R. Parham, S. R. Panchani, S. Natarajan, J. L. Jackson, A. Mu, Y. Tan, K. Q. Cai, A. Klein-Szanto, A. B. Muir, M.-P. Tetreault, K. E. Hamilton, K. A. Whelan

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

bioRxiv · Sep 20, 2023 · PreprintPhysiology

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

C. Ogier, A. M. Charles Solomon, Z. Lu, L. Recoules, A. Klochkova, L. Gabitova-Cornell, B. Bayarmagnai, D. Restifo, A. Surumbayeva, D. B. Vendramini-Costa, A. Deneka, R. Francescone, A. C. Lilly, A. Sipman, J. C. Gardiner, , I. Astsaturov

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis

A. D. Fuller, A. L. Karami, M. F. Kabir, A. Klochkova, J. L. Jackson, A. Mu, Y. Tan, A. Klein-Szanto, K. A. Whelan

This study compares single-cell RNA-sequencing data from murine models of eosinophilic esophagitis (EoE) and esophageal squamous cell carcinoma (ESCC) to show that EoE inflammation limits esophageal carcinogenesis through distinct epithelial remodeling.

bioRxiv · Nov 28, 2022 · PreprintCell Biology

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

N. M. Johnson, L. R. Parham, J. Na, K. E. Monaghan, H. M. Kolev, A. Klochkova, M. S. Kim, C. H. Danan, Z. Cramer, L. A. Simon, K. E. Naughton, S. Adams-Tzivelekidis, Y. Tian, P. A. Williams, N. A. Leu, , K. E. Hamilton

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

bioRxiv · Apr 8, 2022Cell Biology

Cholesterol deprivation induces TGFβ signaling to promote basal differentiation in pancreatic cancer

L. G. Cornell, S. Peri, D. Restifo, A. Klochkova, T. R. Hartman, A. M. O'Reilly, R. Francescone, J. Franco-Barraza, N. Shah, E. Nicolas, E. A. Handorf, K. Q. Cai, A. Mazitova, I. Sloma, R. Chiaverelli, , I. Astsaturov

The paper shows that cholesterol deprivation activates TGFβ signaling, promoting basal differentiation in pancreatic cancer by stabilizing the TGFβ receptor.

bioRxiv · May 11, 2019 · PreprintCancer Biology