Author

H. O. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

J. D. Forman-Kay· 2 shared M. L. Nosella· 2 shared M. Tereshchenko· 2 shared A. A. Hyman· 1 shared A. C. Murthy· 1 shared A. Chong· 1 shared A. F. Palazzo· 1 shared A. Hermann· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. D. Forman-Kay

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Author profile →

4 papers

Recent·Most cited

Cytoplasmic protein-free mRNA induces stress granules by two G3BP1/2-dependent mechanisms

S. J. Ihn, L. Farlam-Williams, A. F. Palazzo, H. O. Lee

The paper shows that protein-free mRNA induces stress granules via two G3BP1/2-dependent mechanisms, one involving PKR and eIF2 phosphorylation, and another independent of PKR and phospho-eIF2.

bioRxiv · Feb 7, 2024 · PreprintCell Biology

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

C. Chin Sang, G. Moore, M. Tereshchenko, M. L. Nosella, H. Zhang, T. R. Alderson, M. Dasovich, A. Leung, I. J. Finkelstein, J. D. Forman-Kay, H. O. Lee

This study shows PARP1 condensates partition DNA repair proteins and enhance DNA ligation through PARylation-dependent mechanisms.

bioRxiv · Jan 20, 2024 · PreprintBiochemistry

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

H. Uechi, S. Sridharan, J. Nijssen, J. Bilstein, J. M. Iglesias-Artola, S. Kishigami, V. Casablancas-Antras, I. Poser, E. J. Martinez, E. Boczek, M. Wagner, N. Tomschke, A. M. de Jesus Domingues, A. Pal, T. Doeleman, , R. J. Wheeler

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

bioRxiv · Jan 5, 2024 · PreprintCell Biology

O-GlcNAcylation reduces phase separation and aggregation of the EWS N-terminal low complexity region

M. L. Nosella, M. Tereshchenko, I. Pritisanac, A. Chong, J. A. Toretsky, H. O. Lee, J. D. Forman-Kay

bioRxiv · May 11, 2021 · PreprintBiochemistry