Neratinib Synergizes with Trastuzumab Antibody Drug Conjugate or with Vinorelbine to Treat HER2 Mutated Breast Cancer Patient Derived Xenografts and Organoids.
S. Li, T. M. Primeau, M. K. Highkin, S. L. Pratt, A. R. Tipton, N. Vemalapally, J. D. Monsey, Y. Tao, J. Luo, I. S. Hagemann, C.-Y. Lin, L. D. Eli, C. X. Ma, R. Bose
The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.
bioRxiv · Dec 19, 2023 · PreprintCancer Biology