Author

R. Bose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. R. Tipton· 2 shared I. S. Hagemann· 2 shared N. Vemalapally· 2 shared S. Li· 2 shared A. Bredemeyer· 1 shared A. Gkogka· 1 shared A. Houston· 1 shared A. Iliuk· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

A. R. Tipton

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Neratinib Synergizes with Trastuzumab Antibody Drug Conjugate or with Vinorelbine to Treat HER2 Mutated Breast Cancer Patient Derived Xenografts and Organoids.

S. Li, T. M. Primeau, M. K. Highkin, S. L. Pratt, A. R. Tipton, N. Vemalapally, J. D. Monsey, Y. Tao, J. Luo, I. S. Hagemann, C.-Y. Lin, L. D. Eli, C. X. Ma, R. Bose

The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.

bioRxiv · Dec 19, 2023 · PreprintCancer Biology

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

M. D. Iglesia, R. G. Jayasinghe, S. Chen, N. V. Terekhanova, J. M. Herndon, E. Storrs, A. Karpova, D. C. Zhou, N. Naser Al Deen, A. T. Shinkle, R. J.-H. Lu, W. Caravan, A. Houston, Y. Zhao, K. Sato, , Marge

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

bioRxiv · Oct 31, 2023Cancer Biology

Oligodendrocyte precursor cells engulf synapses in a model of the developing human forebrain

A. Gkogka, S. Malwade, M. Koskuvi, R. Bose, S. Ceccatelli, J. Koistinaho, J. Tiihonen, M. Schalling, S. S, C. Sellgren-Majkowitz

The paper shows human OPCs engulf synapses in a forebrain organoid model, suggesting a role in synapse elimination during development.

bioRxiv · Sep 4, 2023 · PreprintNeuroscience

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

A. J. Samelson, N. Ariqat, J. McKetney, G. Rohanitazangi, C. Parra Bravo, R. Bose, K. J. Travaglini, V. L. Lam, D. Goodness, G. Dixon, E. Marzette, J. Jin, R. Tian, E. Tse, R. Abskharon, , M. Kampmann

The paper uses CRISPR screens in iPSC-derived neurons to identify factors controlling tau aggregation, finding new pathways and potential therapeutic targets for tauopathies.

bioRxiv · Jun 16, 2023Cell Biology

Breast cancer mutations HER2 V777L and PIK3CA H1047R activate the p21/CDK4/6/Cyclin D1 axis driving tumorigenesis and drug resistance.

X. Cheng, Y. Sun, M. Highkin, N. Vemalapally, X. Jin, B. Zhou, J. L. Prior, A. R. Tipton, S. Li, A. Iliuk, S. Achilefu, I. S. Hagemann, J. R. Edwards, R. Bose

This study investigates how HER2 V777L and PIK3CA H1047R mutations drive breast cancer tumorigenesis and drug resistance, showing effective combination therapies.

bioRxiv · Nov 9, 2022 · PreprintCancer Biology

Stimulation of the Dorsal Root Ganglion using an Injectrode

A. N. Dalrymple, J. E. Ting, R. Bose, J. K. Trevathan, S. Nieuwoudt, S. F. Lempka, M. Franke, K. A. Ludwig, A. Shoffstall, L. E. Fisher, D. J. Weber

This study compares the effectiveness of an injectable polymer electrode (Injectrode) and a traditional metal electrode in stimulating dorsal root ganglion afferent fibers, finding similar activation thresholds and recruitment rates.

bioRxiv · Aug 16, 2021Bioengineering