C.-Y. Lin

StomaVision: stomatal trait analysis through deep learning

StomaVision automates stomatal trait analysis from micrographs, revealing physiological responses to heat stress across plant species.

Neratinib Synergizes with Trastuzumab Antibody Drug Conjugate or with Vinorelbine to Treat HER2 Mutated Breast Cancer Patient Derived Xenografts and Organoids.

The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.

Chromosome-level genome assemblies of two hemichordates provide new insights into deuterostome origin and chromosome evolution

This study presents chromosome-level genome assemblies of two hemichordates to infer deuterostome ancestral chromosomal architecture and lineage-specific modifications.

Insights into RAG evolution from the identification of "missing link" family A RAGL transposons

The paper identifies RAGL-A transposons in invertebrates, showing they share features with both RAG and RAGL-B, suggesting they are a critical intermediate in RAG evolution.

Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

The paper uses a lab-on-CMOS biosensor to track macrophage growth and develops a temporal model to describe growth kinetics over 30 hours.

Synergistic Binding of the Halide and Cationic Prime Substrate of the L-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

This paper investigates the synergistic binding of halide and cationic substrates in the BesD enzyme across different iron states, revealing cooperative interactions and decay pathways.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

Sex- and Age-dependent Skin Mechanics - A Detailed Look in Mice

This study investigates age- and sex-dependent changes in skin mechanics in mice using mechanical testing, histology, collagen assays, and two-photon microscopy, revealing sex differences in stiffness that emerge with age.

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.

Insights into deuterostome evolution from the biphasic transcriptional programmes of hemichordates

This study identifies a biphasic developmental program in hemichordates, revealing conserved gene regulatory networks and cis-regulatory elements across deuterostomes.

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

This study shows SMN regulates mitochondrial metabolic maturation during myogenesis by controlling the MYOD-miRNA axis, with miR-1 and miR-206 supplementation restoring mitochondrial function in SMN-deficient cells.

Peptide-based drug predictions for cancer therapy using deep learning

This paper develops AI4ACP, a web-server for predicting anticancer peptides, showing improved performance over existing predictors.

In vivo correction of cystic fibrosis mediated by PNA nanoparticles

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

Developing an Antiviral Peptides Predictor with Generative Adversarial Network Data Augmentation

The paper develops a binary classifier for identifying antiviral peptides using a GAN-augmented dataset and achieves high performance on a test set.

Discovering Novel Antimicrobial Peptides in Generative Adversarial Network

This study uses a deep convolutional GAN to generate novel antimicrobial peptides, which show antibacterial activity, including against antibiotic-resistant strains.

Thymic macrophages consist of two populations with distinct localization and origin

This study identifies two distinct thymic macrophage populations with different locations and origins using single-cell RNA sequencing and genetic fate mapping.

Donor Macrophages Modulate Rejection after Heart Transplantation

This study identifies donor CCR2+ macrophages as key drivers of heart transplant rejection and shows that inhibiting MYD88 signaling in these cells extends graft survival.

Engineering sorghum for higher 4-hydroxybenzoic acid content

This paper engineers sorghum to overproduce 4-hydroxybenzoic acid by expressing modified bacterial enzymes, resulting in 1.56-1.72% dry weight accumulation without affecting biomass or agronomic traits.

AI4AMP: Sequence-based antimicrobial peptides predictor using physicochemical properties-based encoding method and deep learning

AI4AMP predicts antimicrobial activity of protein sequences using physicochemical properties encoding and deep learning, outperforming existing predictors.

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

Estrogen receptor β exerts tumor suppressive effects in prostate cancer through repression of androgen receptor activity

This study shows that estrogen receptor β suppresses prostate cancer by reducing androgen receptor activity through gene expression and metabolic changes.

Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling

The paper develops a method to rapidly deplete tubulin glutamylation in primary cilia, revealing its role in intraflagellar transport and Hedgehog signaling without affecting other PTMs.