Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells
R. P. Sparks, A. S. Arango, Z. L. Aboff, J. L. Jenkins, W. C. Guida, E. Tajkhorshid, C. E. Sparks, J. D. Sparks, R. A. Fratti
The paper investigates how a small molecule alters Sortilin's function, affecting ApoB and PCSK9 trafficking in liver cells and revealing a conserved mechanism in yeast.
bioRxiv · Oct 7, 2019 · PreprintBiochemistry