J. L. Jenkins

A UHM - ULM interface contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

This study determines the crystal structure of the U2AF2 UHM-SF3B1 ULM interface and shows its role in pre-mRNA splicing and co-regulation with SF1.

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

This study investigates how U2AF2 recognizes different nucleotides at the center of the Py tract in pre-mRNA splice sites using structural and functional analyses.

Multi-Species Phenotypic Screening across Disease Models of Mucolipidosis Type IV

The paper screens a compound library across invertebrate and human models of mucolipidosis IV to identify conserved disease modifiers, finding cyclin-dependent kinase inhibition as a potential therapeutic strategy.

Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

The paper identifies a small molecule that inhibits pre-mRNA splicing by stabilizing an early-stage U2AF2-RNA complex, offering a new strategy for targeting spliceosome assembly.

Multi-modal Nonlinear Optical and Thermal Imaging Platform for Label-Free Characterization of Biological Tissue

This paper introduces a multimodal imaging platform that combines nonlinear optical and thermal imaging to characterize biological tissues without labels.

A Splice Site-Sensing Conformational Switch in U2AF2 is Modulated by U2AF1 and its Recurrent Myelodysplasia-Associated Mutation

This study investigates how U2AF1 and its S34F mutation affect U2AF2 conformational dynamics and RNA binding using single-molecule FRET.

Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells

The paper investigates how a small molecule alters Sortilin's function, affecting ApoB and PCSK9 trafficking in liver cells and revealing a conserved mechanism in yeast.

Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers

This study shows phosphatidic acid (PA) inhibits SNARE priming by altering Sec18 conformation and stabilizing membrane-bound protomers.