Author
R. A. Fratti
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2022 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 33 mutual co-author links8 papers
Recent·Most cited
Reciprocal regulation of vacuolar calcium transport and V-ATPase activity, and the effects of Phosphatidylinositol 3,5-bisphosphate
G. E. Miner, D. A. Rivera-Kohr, C. Zhang, K. D. Sullivan, A. Guo, R. A. Fratti
This study shows that Ca2+ and H+ transport across the yeast vacuole membrane are reciprocally regulated and linked to Phosphatidylinositol 3,5-bisphosphate production.
bioRxiv · May 22, 2020 · PreprintBiochemistry
Sphingolipids regulate the tethering stage of vacuole fusion by affecting membrane fluidity
C. Zhang, L. R. Hurst, Z. D. Gokbayrak, J. D. Calderin, M. R. Hrabak, A. Balutowski, D. A. Rivera-Kohr, T. D. D. Kazmirchuk, C. L. Brett, R. A. Fratti
This study shows that sphingolipids with very long-chain fatty acids regulate vacuole fusion by affecting membrane fluidity and Ypt7 function in yeast.
bioRxiv · Feb 17, 2020 · PreprintCell Biology
Non-Canonical Binding of a Small Molecule to Sortilin Alters Cellular Trafficking of ApoB and PCSK9 in Liver Derived Cells
R. P. Sparks, A. S. Arango, Z. L. Aboff, J. L. Jenkins, W. C. Guida, E. Tajkhorshid, C. E. Sparks, J. D. Sparks, R. A. Fratti
The paper investigates how a small molecule alters Sortilin's function, affecting ApoB and PCSK9 trafficking in liver cells and revealing a conserved mechanism in yeast.
bioRxiv · Oct 7, 2019 · PreprintBiochemistry
Copper Blocks V-ATPase Activity and SNARE Complex Formation to Inhibit Yeast Vacuole Fusion
G. E. Miner, K. D. Sullivan, C. Zhang, L. R. Hurst, M. L. Starr, D. A. Rivera-Kohr, B. C. Jones, A. Guo, R. A. Fratti
This study shows that copper inhibits yeast vacuole fusion by blocking SNARE complex formation and V-ATPase activity, with Cu2+ being the active species.
bioRxiv · May 2, 2019Biochemistry
Phosphatidylinositol 3,5-Bisphosphate regulates Ca2+ Transport During Yeast Vacuolar Fusion through Activation of the Ca2+ ATPase Pmc1
G. E. Miner, K. D. Sullivan, A. Guo, M. L. Starr, E. C. Ellis, B. C. Jones, R. A. Fratti
This study shows that PI(3,5)P2 regulates Ca2+ transport in yeast vacuoles by activating Pmc1 during fusion, opposing its role in fission.
bioRxiv · Feb 1, 2019Biochemistry
Phosphatidylinositol 3,5-Bisphosphate Regulates Yeast Vacuole Fusion at the Transition between trans-SNARE Complex Formation and Hemifusion
G. E. Miner, K. D. Sullivan, A. Guo, B. C. Jones, M. L. Starr, R. A. Fratti
This study shows that PI(3,5)P2 inhibits yeast vacuole fusion after SNARE complex formation and during hemifusion, acting as a molecular switch between fission and fusion.
bioRxiv · Aug 10, 2018Biochemistry
Phosphatidic acid inhibits SNARE priming by inducing conformational changes in Sec18 protomers
M. L. Starr, R. A. Sparks, L. R. Hurst, Z. Zhao, A. Arango, M. Lihan, J. L. Jenkins, E. Tajkhorshid, R. A. Fratti
This study shows phosphatidic acid (PA) inhibits SNARE priming by altering Sec18 conformation and stabilizing membrane-bound protomers.
bioRxiv · Jul 9, 2018Biochemistry