Microbiota-derived aspartate drives pathogenic Enterobacteriaceae expansion in the inflamed gut
W. Yoo, J. K. Zieba, N. G. Shealy, T. P. Torres, J. D. Thomas, C. D. Shelton, N. J. Foegeding, E. E. Olsan, M. X. Byndloss
This study shows that inflammation increases intestinal aspartate levels, which pathogens like S. Tm and E. coli use via aspA to grow during colitis.
bioRxiv · Feb 14, 2022 · PreprintMicrobiology