J. L. Henty-Ridilla

This study develops yeast strains expressing human β- or γ-actin as their sole source, enabling purification of these actin isoforms for biochemical studies.

This study investigates IQGAP1's role in regulating actin plus-end dynamics by displacing formin and capping protein, affecting cell morphology and migration.

This study investigates how ALS-associated profilin variants affect actin assembly through biochemical assays and finds that some variants impair actin elongation when formin is present.

The paper develops genetically encoded tagged versions of PFN1 to study its interactions with actin and microtubules in vitro and in live cells, revealing functional insights into PFN1's role in cellular processes and disease.

This study shows TGFβ2 increases HTM cell contractility via ERK and ROCK pathways, with distinct crosstalk depending on the culture substrate.

This paper shows that inhibiting ITK in donor T cells reduces GVHD while preserving GVT effects in allo-HSCT using murine models and a novel peptide inhibitor.

This study identifies profilin 1's role in regulating actin network assembly, organization, and dynamics through internetwork competition and collaboration at the leading edge.