Author

J. de Ligt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Cuppen· 2 shared A. F. M. Altelaar· 1 shared A. J. R. Heck· 1 shared A. Lyubimova· 1 shared A. Papaspyropoulos· 1 shared A. Prahallad· 1 shared A. Ressa· 1 shared A. van Oudenaarden· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

E. Cuppen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An emergent clade of SARS-CoV-2 linked to returned travellers from Iran

J.-S. Eden, R. Rockett, I. Carter, H. Rahman, J. de Ligt, J. Hadfield, M. Storey, X. Ren, R. Tulloch, K. Basile, J. Wells, R. Byun, N. Gliroy, M. V. O'Sullivan, V. Sintchenko, , J. Kok

The paper identifies a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand through whole genome sequencing and phylogenetic analysis.

bioRxiv · Mar 15, 2020Microbiology

Long-term expanding human airway organoids for disease modelling.

N. Sachs, D. D. Zomer-van Ommen, A. Papaspyropoulos, I. Heo, L. Bottinger, D. Klay, F. Weeber, G. Huelsz-Prince, N. Iakobachvili, M. C. Viveen, A. Lyubimova, L. Teeven, S. Derakhshan, J. Korving, H. Begthel, , H. Clevers

This study establishes long-term-expanding human airway organoids from broncho-alveolar biopsies or lavage material, enabling disease modeling of cystic fibrosis, lung cancer, and RSV infection.

bioRxiv · May 9, 2018Cell Biology

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

A. Ressa, E. Bosdriesz, J. de Ligt, S. Mainardi, G. Maddalo, A. Prahallad, M. Jager, L. de la Fonteijne, M. Fitzpatrick, S. Groten, A. F. M. Altelaar, R. R. Bernards, E. Cuppen, L. Wessels, A. J. R. Heck

The paper investigates molecular responses to BRAF and EGFR inhibition in colorectal cancer cells, revealing metabolic shifts and MAPK pathway reactivation.

bioRxiv · Sep 27, 2017Cancer Biology