Acquired deficiency of the peroxisomal enzyme enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is a metabolic vulnerability in hepatoblastoma
H. Wang, X. Chen, M. Schwalbe, J. E. Gorka, J. A. Mandel, J. Wang, J. Lu, E. S. Goetzman, S. Dobrowolski, E. V. Prochownik
This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.
bioRxiv · Aug 24, 2020 · PreprintCancer Biology