Author

J. A. Mandel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

E. V. Prochownik· 2 shared H. Wang· 2 shared J. Lu· 2 shared J. Wang· 2 shared M. Schwalbe· 2 shared B. Marburger· 1 shared E. S. Goetzman· 1 shared J. E. Gorka· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

E. V. Prochownik

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2 papers

Recent·Most cited

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas

H. Wang, J. Lu, J. A. Mandel, W. Zhang, M. Schwalbe, J. Gorka, Y. Liu, B. Marburger, J. Wang, S. Ranganathan, E. V. Prochownik

This study shows that patient-derived NFE2L2 mutants drive aggressive hepatoblastomas in mice by accelerating tumor growth and promoting necrosis and cyst formation.

bioRxiv · Sep 13, 2020Cancer Biology

Acquired deficiency of the peroxisomal enzyme enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is a metabolic vulnerability in hepatoblastoma

H. Wang, X. Chen, M. Schwalbe, J. E. Gorka, J. A. Mandel, J. Wang, J. Lu, E. S. Goetzman, S. Dobrowolski, E. V. Prochownik

This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.

bioRxiv · Aug 24, 2020 · PreprintCancer Biology