Author

E. V. Prochownik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:development & morphogenesis· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

H. Wang· 5 shared J. Lu· 5 shared A. Roberts· 3 shared J. Wang· 3 shared J. A. Mandel· 2 shared M. Schwalbe· 2 shared r. muzumdar· 2 shared S. Ranganathan· 2 shared

Activity by Year

2017-2023 · peak 2/yr

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10 top collaborators · 34 mutual co-author links

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5 shared papersCancer Biology

H. Wang

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6 papers

Recent·Most cited

The Myc-Like Mlx Network Impacts Aging and Metabolism

H. Wang, T. Stevens, J. Lu, A. Roberts, C. Land, r. muzumdar, z. gong, J. Vockley, E. V. Prochownik

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

bioRxiv · Nov 26, 2023 · PreprintCancer Biology

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc Inactivation

H. Wang, J. Lu, T. Stevens, A. Roberts, J. Mandel, R. Avula, B. Ma, Y. Wu, J. Wang, T. Finkel, C. Van't Land, J. E. Vockley, M. Airik, R. Airik, R. Muzumdar, , E. V. Prochownik

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

bioRxiv · Jan 30, 2023 · PreprintCancer Biology

Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia

H. Wang, J. Lu, F. Alencastro, A. Roberts, J. Fiedor, P. Carroll, R. Eisenman, S. Ranganathan, M. Torbenson, A. W. Duncan, E. V. Prochownik

This study investigates the interaction between the Myc and Mlx networks in liver regeneration and tumorigenesis, finding that the Mlx network plays a critical role in maintaining homeostasis and suppressing tumor formation.

bioRxiv · Aug 5, 2021Cancer Biology

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas

H. Wang, J. Lu, J. A. Mandel, W. Zhang, M. Schwalbe, J. Gorka, Y. Liu, B. Marburger, J. Wang, S. Ranganathan, E. V. Prochownik

This study shows that patient-derived NFE2L2 mutants drive aggressive hepatoblastomas in mice by accelerating tumor growth and promoting necrosis and cyst formation.

bioRxiv · Sep 13, 2020Cancer Biology

Acquired deficiency of the peroxisomal enzyme enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is a metabolic vulnerability in hepatoblastoma

H. Wang, X. Chen, M. Schwalbe, J. E. Gorka, J. A. Mandel, J. Wang, J. Lu, E. S. Goetzman, S. Dobrowolski, E. V. Prochownik

This study shows that reducing the peroxisomal enzyme Ehadh in hepatoblastoma makes tumors more susceptible to a fatty acid metabolite, suggesting a potential metabolic therapy.

bioRxiv · Aug 24, 2020 · PreprintCancer Biology

Diagnostic and Prognostic Implications of Ribosomal Protein Transcript Coordination in Human Cancers

J. M. Dolezal, A. P. Dash, E. V. Prochownik

The paper examines ribosomal protein transcript (RPT) expression patterns in tumors and normal tissues, showing distinct patterns that correlate with tumor subtypes, molecular features, and patient survival.

bioRxiv · Jul 24, 2017Cancer Biology