Author

J. E. Irazoqui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:C. elegans· 4 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

X. Gonzalez· 3 shared D. Goswamy· 2 shared K. A. Wani· 2 shared A. Ghazi· 1 shared A. Wood· 1 shared B. Koscso· 1 shared H. A. Tissenbaum· 1 shared H. H. Honwad· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

X. Gonzalez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TFEB-Mediated Pro-inflammatory Response in Murine Macrophages Induced by Acute Alpha7 Nicotinic Receptor Activation

H. H. Honwad, M. Najibi, B. Koscso, M. Bogunovic, J. E. Irazoqui

This study shows that activating the alpha7 nicotinic receptor in macrophages triggers TFEB nuclear translocation and a pro-inflammatory gene signature without cytokine release.

bioRxiv · Jan 26, 2024Immunology

Glucose-fed microbiota alters intestinal epithelium and increases susceptibility to bacterial pathogens

S. F. Kingsley, Y. Seo, A. Wood, K. A. Wani, X. Gonzalez, J. E. Irazoqui, S. E. Finkel, H. A. Tissenbaum

This study shows that a glucose-fed microbiota in C. elegans reduces lifespan and healthspan, increases intestinal permeability, and raises susceptibility to bacterial pathogens.

bioRxiv · Nov 19, 2023 · PreprintPhysiology

Distinct members of the C. elegans CeMbio reference microbiota exert cryptic virulence and infection protection

X. Gonzalez, J. E. Irazoqui

This study identifies cryptic virulence and protective roles of individual CeMbio bacteria in C. elegans, highlighting the importance of HLH-30/TFEB in host defense.

bioRxiv · Nov 2, 2023 · PreprintImmunology

Negative regulation of C. elegans innate immunity by orphan nuclear receptor NHR-42

D. Goswamy, S. A. Labed, X. Gonzalez, J. E. Irazoqui

This study identifies nhr-42 as a negative regulator of host defense genes in C. elegans, showing it limits immune response and reallocates energy resources post-infection.

bioRxiv · Sep 12, 2022 · PreprintImmunology

NHR-49/PPAR-α and HLH-30/TFEB promote C. elegans host defense via a flavin-containing monooxygenase

K. A. Wani, D. Goswamy, S. Taubert, R. Ratnappan, A. Ghazi, J. E. Irazoqui

This study identifies NHR-49/PPAR-α and HLH-30/TFEB as regulators of an infection-specific host response in C. elegans, revealing FMOs as innate immunity effectors.

bioRxiv · Sep 3, 2020Microbiology