Author

J. E. Toombs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

J. Lorens· 2 shared N. Z. Phinney· 2 shared R. A. Brekken· 2 shared A. Mai· 1 shared A. Rizvi· 1 shared C. E. Tiron· 1 shared D. Micklem· 1 shared E. N. Arner· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

J. Lorens

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2 papers

Recent·Most cited

AXL-TBK1 driven nuclear AKT3 promotes metastasis

E. N. Arner, J. M. Westcott, S. Hinz, C. E. Tiron, M. Blo, A. Mai, R. Virtakoivu, N. Z. Phinney, S. Nord, K. Y. Aguilera, A. Rizvi, J. E. Toombs, T. Reese, V. Fey, D. Micklem, , R. A. Brekken

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

W. Du, H. Huang, Z. Wang, J. E. Toombs, N. Z. Phinney, Y. Zhang, M. S. Beg, T. M. Wilkie, J. Lorens, R. A. Brekken

This study identifies AXL as a key driver of cell plasticity and metastasis in pancreatic cancer using single-cell RNA sequencing and mouse models.

bioRxiv · Jul 6, 2020Cancer Biology