Author

J. M. Westcott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

R. A. Brekken· 2 shared A. Mai· 1 shared A. Rizvi· 1 shared A. W. Whitehurst· 1 shared C. E. Tiron· 1 shared C.-C. Cheng· 1 shared D. Micklem· 1 shared D. Segal· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

R. A. Brekken

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Imaging of cellular dynamics in vitro and in situ: from a whole organism to sub-cellular imaging with self-driving, multi-scale microscopy

S. Daetwyler, H. Mazloom-Farsibaf, F. Y. Zhou, D. Segal, E. Sapoznik, J. M. Westcott, R. A. Brekken, G. Danuser, R. P. Fiolka

The paper introduces a self-driving, multi-resolution light-sheet microscope to simultaneously observe sub-cellular dynamics and whole organisms over extended periods, applying it to study development, cancer, and immune interactions in zebrafish.

bioRxiv · Feb 28, 2024 · PreprintBioengineering

AXL-TBK1 driven nuclear AKT3 promotes metastasis

E. N. Arner, J. M. Westcott, S. Hinz, C. E. Tiron, M. Blo, A. Mai, R. Virtakoivu, N. Z. Phinney, S. Nord, K. Y. Aguilera, A. Rizvi, J. E. Toombs, T. Reese, V. Fey, D. Micklem, , R. A. Brekken

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGF-beta; signaling in triple-negative breast cancer

Z. A. Gibbs, L. C. Reza, C.-C. Cheng, J. M. Westcott, K. McGlynn, A. W. Whitehurst

The paper identifies ZNF165 as a SMAD3 cofactor that enhances TGF-beta signaling in triple-negative breast cancer, promoting tumor growth and survival.

bioRxiv · Apr 4, 2020Cancer Biology