Systemic immune dysfunction in cancer patients driven by IL6 and IL8 induction of an inhibitory receptor module in peripheral CD8+ T cells
A. Somasundaram, A. R. Cillo, C. Lampenfeld, L. Oliveri, M. A. Velez, S. Joyce, M. J. Calderon, R. Dadey, D. Rajasundaram, D. P. Normolle, S. C. Watkins, J. G. Herman, J. M. Kirkwood, E. J. Lipson, R. L. Ferris, , D. A. A. Vignali
This study identifies a systemic immune dysfunction in cancer patients driven by IL6 and IL8, leading to CD8+ T cell dysfunction and poor prognosis.
bioRxiv · May 6, 2020 · PreprintCancer Biology