Expression of Tim-3 drives naive Treg to an effector-like state with enhanced suppressive activity
H. Banerjee, H. Nieves-Rosado, A. Kulkarni, B. Murter, U. R. Chandran, A. Chang, A. L. Szymczak-Workman, L. Vujanovic, R. L. Ferris, L. P. Kane
The paper shows that Tim-3 expression in Treg cells drives them to an effector-like state with enhanced suppressive activity, promoting tumor growth.
bioRxiv · Jul 31, 2020 · PreprintImmunology