Author

A. Somasundaram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:fluorescence / live-cell microscopy· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. R. Cillo· 3 shared J. W. Taraska· 3 shared T. C. Bruno· 3 shared A. Morris· 2 shared A. Ray· 2 shared B. J. McVerry· 2 shared B. Methe· 2 shared C. J. Workman· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

A. R. Cillo

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Author profile →

6 papers

Recent·Most cited

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

S. P. Peddireddy, S. A. Rahman, A. R. Cillo, G. M. Vijay, A. Somasundaram, C. J. Workman, W. Bain, B. J. McVerry, B. Methe, J. S. Lee, P. Ray, A. Ray, T. C. Bruno, D. A. Vignali, G. D. Kitsios, , J. Das

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

bioRxiv · Jan 24, 2022Immunology

Bifurcated monocyte states are predictive of mortality in severe COVID-19

A. R. Cillo, A. Somasundaram, F. Shan, C. Cardello, C. J. Workman, G. D. Kitsios, A. Ruffin, S. Kunning, C. Lampenfeld, S. Onkar, S. Grebinowski, G. Deshmukh, B. Methe, C. Liu, S. Nambulli, , D. A. Vignali

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

bioRxiv · Feb 10, 2021 · PreprintImmunology

The structure and spontaneous curvature of clathrin lattices at the plasma membrane.

K. A. Sochacki, B. L. Heine, G. J. Haber, J. R. Jimah, B. Prasai, M. A. Alfonzo-Mendez, A. D. Roberts, A. Somasundaram, J. E. Hinshaw, J. W. Taraska

This study determines the structural framework of clathrin-mediated endocytosis, showing flat clathrin lattices spontaneously curve into coated pits without external factors.

bioRxiv · Jul 18, 2020Cell Biology

Systemic immune dysfunction in cancer patients driven by IL6 and IL8 induction of an inhibitory receptor module in peripheral CD8+ T cells

A. Somasundaram, A. R. Cillo, C. Lampenfeld, L. Oliveri, M. A. Velez, S. Joyce, M. J. Calderon, R. Dadey, D. Rajasundaram, D. P. Normolle, S. C. Watkins, J. G. Herman, J. M. Kirkwood, E. J. Lipson, R. L. Ferris, , D. A. A. Vignali

This study identifies a systemic immune dysfunction in cancer patients driven by IL6 and IL8, leading to CD8+ T cell dysfunction and poor prognosis.

bioRxiv · May 6, 2020 · PreprintCancer Biology

Local Protein Dynamics During Microvesicle Exocytosis in Neuroendocrine Cells

A. Somasundaram, J. W. Taraska

The paper uses live-cell imaging to study protein dynamics during microvesicle exocytosis in neuroendocrine cells, revealing roles of endocytic proteins in regulating exocytosis.

bioRxiv · Mar 20, 2018Cell Biology

Semisynthetic pH-Sensitive Fluorophores For Imaging Exocytosis And Endocytosis

M. Martineau, A. Somasundaram, J. B. Grimm, T. D. Gruber, D. Choquet, J. W. Taraska, L. D. Lavis, D. Perrais

This paper develops semisynthetic pH-sensitive fluorophores that enable imaging of exocytosis and endocytosis, matching the performance of GFP-based pHluorin.

bioRxiv · Mar 25, 2017Cell Biology