Author

K. A. Sochacki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8

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Research Focus:cell signaling & trafficking· 7 Approach:microscopy & imaging analysis· 5 Assay:fluorescence / live-cell microscopy· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:cryo-EM· 1 Assay:electronic health records· 1

Frequent Co-Authors

J. W. Taraska· 7 shared M.-P. Strub· 3 shared A. D. Roberts· 2 shared A. M. Dickey· 2 shared B. Prasai· 2 shared G. J. Haber· 2 shared M. A. Alfonzo-Mendez· 2 shared A. D. Hoppe· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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7 shared papersCell Biology

J. W. Taraska

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8 papers

Recent·Most cited

Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly

M. A. Quintanilla, H. Patel, H. Wu, K. A. Sochacki, M. Akamatsu, J. D. Rotty, F. Korobova, J. E. Bear, J. W. Taraska, P. W. Oakes, J. R. Beach

This study identifies biophysical mechanisms regulating non-muscle myosin 2 filament assembly using dynamic imaging and optogenetic tools, showing myosin monomer concentration and myosin:myosin interactions drive filament formation.

bioRxiv · Apr 26, 2023Cell Biology

A conformational switch in clathrin light chain regulates lattice structure and endocytosis at the plasma membrane of mammalian cells.

K. Obashi, K. A. Sochacki, M.-P. Strub, J. W. Taraska

bioRxiv · Mar 21, 2022Cell Biology

Dual clathrin and adhesion signaling systems regulate growth factor receptor activation

M. A. Alfonzo-Mendez, K. A. Sochacki, M.-P. Strub, J. W. Taraska

The paper reveals how clathrin lattices and adhesion receptors interact to regulate growth factor signaling through coordinated crosstalk between EGFR and β5-integrin.

bioRxiv · Nov 9, 2020 · PreprintCell Biology

The nanoscale anatomy of exocytic dense-core vesicles in neuroendocrine cells

B. Prasai, G. J. Haber, M.-P. Strub, J. A. Ciemniecki, K. A. Sochacki, J. W. Taraska

This study maps Rab-GTPases and their effectors at the nanoscale in exocytic dense-core vesicles using advanced imaging techniques and reveals their circumferential distribution on vesicles.

bioRxiv · Aug 19, 2020 · PreprintCell Biology

Structurally distinct endocytic pathways for B cell receptors in B lymphocytes

A. D. Roberts, T. M. Davenport, A. M. Dickey, R. Ahn, K. A. Sochacki, J. W. Taraska

This study shows that B cells use different endocytic mechanisms depending on BCR cluster size, switching from clathrin-mediated endocytosis to large membrane invaginations with actin and FCHSD2 recruitment.

bioRxiv · Jul 24, 2020Cell Biology

The structure and spontaneous curvature of clathrin lattices at the plasma membrane.

K. A. Sochacki, B. L. Heine, G. J. Haber, J. R. Jimah, B. Prasai, M. A. Alfonzo-Mendez, A. D. Roberts, A. Somasundaram, J. E. Hinshaw, J. W. Taraska

This study determines the structural framework of clathrin-mediated endocytosis, showing flat clathrin lattices spontaneously curve into coated pits without external factors.

bioRxiv · Jul 18, 2020Cell Biology

Focal adhesion-generated cues in extracellular matrix regulate cell migration by local induction of clathrin-coated plaques

D. Bucher, M. Mukenhirn, K. A. Sochacki, V. Saharuka, C. Huck, C. Zambarda, j. Taraska, E. A. Cavalcanti-Adam, S. Boulant

This study identifies Eps15 and Eps15R as key regulators of clathrin-coated plaque formation, linking ECM remodeling by focal adhesions to cell migration directionality.

bioRxiv · Dec 11, 2018 · PreprintCell Biology

Membrane bending begins at any stage of clathrin-coat assembly and defines endocytic dynamics

B. L. Scott, K. A. Sochacki, S. T. Low-Nam, E. M. Bailey, Q. Luu, A. Hor, A. M. Dickey, S. Smith, J. G. Kerkvliet, J. W. Taraska, A. D. Hoppe

The paper uses advanced imaging techniques to study membrane bending during clathrin-coat assembly and finds that bending occurs at different stages of the process, challenging existing models.

bioRxiv · Jul 13, 2017Cell Biology