Author

J. G. Okun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. J. Rose· 1 shared A. Jungmann· 1 shared A. Y. Chan· 1 shared A. Zota· 1 shared B. Dimitrov· 1 shared G. A. Bezerra· 1 shared H. J. Bailey· 1 shared J. Rutter· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPhysiology

A. J. Rose

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2 papers

Recent·Most cited

An endocrine-hepato-muscular metabolic cycle links skeletal muscle atrophy and hyperglycemia in type 2 diabetes

J. G. Okun, P. M. Rusu, A. Y. Chan, Y. W. Yap, T. Sharkie, J. Schumacher, S. Hille, K. Schmidt, A. Zota, A. Jungmann, L. Maggi, Y. Lee, M. Blueher, S. Herzig, M. Heikenwaelder, , A. J. Rose

This study identifies an endocrine-hepato-muscular metabolic cycle linking hyperglycemia and skeletal muscle atrophy in type 2 diabetes through dysregulated alanine metabolism and ALT enzyme activity.

bioRxiv · May 25, 2020 · PreprintPhysiology

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

G. A. Bezerra, W. R. Foster, H. J. Bailey, K. G. Hicks, S. W. Sauer, B. Dimitrov, J. G. Okun, J. Rutter, S. Koelker, W. W. Yue

This study presents the crystal structure of human DHTKD1 and a 3D reconstruction of the DLST inner core, revealing structural insights into lysine catabolism and potential drug targets.

bioRxiv · Jan 20, 2020Biochemistry