Author

A. Y. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2

Frequent Co-Authors

A. J. Rose· 2 shared A. Jungmann· 2 shared B. Miao· 2 shared C. Mandel-Brehm· 2 shared E. M. N. Ferre· 2 shared J. L. DeRisi· 2 shared M. S. Anderson· 2 shared M. S. Lionakis· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

A. J. Rose

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq

S. E. Vazquez, S. A. Mann, A. Bodansky, A. F. Kung, Z. Quandt, E. M. N. Ferre, N. Landegren, D. Eriksson, P. Bastard, S.-Y. Zhang, J. Liu, A. Mitchell, C. Mandel-Brehm, B. Miao, G. Sowa, , J. L. DeRisi

This paper scales PhIP-Seq for autoantibody discovery across multiple autoimmune diseases and COVID19, enabling machine learning predictions and identification of disease-specific autoantigens.

bioRxiv · Mar 23, 2022Immunology

Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts

A. M. Nicks, S. R. Holman, A. Y. Chan, M. Tsang, P. E. Young, D. T. Humphreys, N. Naqvi, A. Husain, M. Li, N. J. Smith, S. E. Iismaa, R. M. Graham

This paper develops a standardized method to isolate and purify high-quality cardiomyocytes from murine hearts of all postnatal ages, revealing sex-specific genes and preserving cell morphology.

bioRxiv · Sep 30, 2021Cell Biology

An endocrine-hepato-muscular metabolic cycle links skeletal muscle atrophy and hyperglycemia in type 2 diabetes

J. G. Okun, P. M. Rusu, A. Y. Chan, Y. W. Yap, T. Sharkie, J. Schumacher, S. Hille, K. Schmidt, A. Zota, A. Jungmann, L. Maggi, Y. Lee, M. Blueher, S. Herzig, M. Heikenwaelder, , A. J. Rose

This study identifies an endocrine-hepato-muscular metabolic cycle linking hyperglycemia and skeletal muscle atrophy in type 2 diabetes through dysregulated alanine metabolism and ALT enzyme activity.

bioRxiv · May 25, 2020 · PreprintPhysiology

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by PhIP-Seq

S. E. Vazquez, E. M. N. Ferre, D. W. Scheel, S. Sunshine, B. Miao, C. Mandel-Brehm, Z. Quandt, A. Y. Chan, M. Cheng, M. S. German, M. S. Lionakis, J. L. DeRisi, M. S. Anderson

This study uses PhIP-Seq to identify novel autoantigens in APS1, linking specific autoantibodies to clinical phenotypes like ovarian insufficiency and intestinal dysfunction.

bioRxiv · Jan 20, 2020Immunology

Restriction of essential amino acids dictates the systemic response to dietary protein dilution

Y. W. Yap, P. M. Rusu, A. Y. Chan, B. C. Fam, A. Jungmann, S. M. Solon-Biet, C. K. Barlow, D. J. Creek, C. Huang, R. B. Schittenhelm, B. Morgan, D. Schmoll, B. Kiens, M. D. Piper, M. Heikenwalder, , A. J. Rose

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.

bioRxiv · Nov 20, 2019 · PreprintPhysiology