Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection
A. J. Wilk, J. O. Marceau, S. W. Kazer, I. Fleming, V. N. Miao, J. Galvez-Reyes, A. K. Shalek, S. Holmes, J. Overbaugh, C. A. Blish
This study identifies pro-inflammatory feedback loops in immune responses to pathogenic lentivirus infection, showing that highly pathogenic variants induce delayed, sustained, and amplifying inflammatory circuits.
bioRxiv · Mar 19, 2023Immunology